Regulation of innate immune response mediated by organelle communication

Innate Immune Response by PSMA7 Negative Regulation of MAVS-Mediated

microRNA-mediated regulation of innate immune response in rheumatic diseases

miRNAs have been shown to play essential regulatory roles in the innate immune system. They function at multiple levels to shape the innate immune response and maintain homeostasis by direct suppression of the expression of their target proteins, preferentially crucial signaling components and transcription factors. Studies in humans and in disease models have revealed that dysregulation of sev...

Decoding the noncoding: Prospective of lncRNA-mediated innate immune regulation

The innate immune system is the first line of defense against microbial pathogens, but tight regulation of gene expression is necessary to prevent the detrimental effects of unrestrained activation. Although the functions of most long noncoding RNAs (lncRNAs; >200 nucleotides) are unknown, many have been shown to regulate diverse cellular activities. Recent reports by us and others have suggest...

Regulation of receptor-dependent activation of the innate immune response.

In the United States, >750,000 patients annually are thought to be at high risk for developing septic shock, with mortality rates reaching 60%. Thus, huge societal and financial costs are associated with this syndrome. Because of the high incidence and poor prognosis of septic shock, basic research has focused on the innate immune system for >2 decades. The pathophysiology of severe sepsis/shoc...

IRF 3 - mediated innate immune response through degradation of activated

3 Huifang Zhu 1, , Chunfu Zheng 1, #, *, Junji Xing , Shuai Wang , Shuping Li , Rongtuan 4 Lin , and Karen L. Mossman 4 5 6 1 Molecular Virology and Viral Immunology Research Group, State Key Laboratory of 7 Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071 China. 8 2 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First 9 Affiliated H...